Porcine Intestinal Adenomatosus

[mikey]

Porcine Intestinal Adenomatosus (Pig Ileitis)
The causes, different clinical forms and control/treatment of ileitis are covered in this article from Meriden Animal Health.


Porcine intestinal adenomatosus (PIA), or more commonly known as pig ileitis, comprises a disease complex with a group of conditions involving pathological changes in the small intestine associated with the intracellular bacterium Lawsonia intracellularis. The organism affects the mucosal epithelium of the small intestine, mostly the ileum and sometimes even the colon, causing hypertrophy, with or without haemorrhage.

The disease affects grower and finisher pigs of aged six to 20 weeks or older. It usually occurs as a mild, chronic infection with diarrhoea and weight loss or retarded growth due to poor feed efficiency. The acute haemorrhagic form is less frequent with bloody scours and sudden death.

Ileitis exists on most, if not all, farms. The disease takes on four different forms:

Porcine intestinal adenomatosus (PIA) – an abnormal proliferation of the cells that line the intestines, resulting in a thickening of the intestines.


Necrotic enteritis (NE) – besides the gross thickening of the small intestine, the proliferated cells die and slough off, resulting in necrotic or ulcerative lesions.


Regional Ileitis (RI) or Terminal Ileitis (TI) – inflammation of the terminal part of the small intestine, and


Proliferative haemorrhagic enteropathy (PHE) – massive bleeding into the small intestine, hence the common name ‘bloody gut’ and this is the most common form in grower and finisher pigs.


PIA: The intestinal wall thickens often with oedema to varying degrees. The mucosae are thrown into folds and may result in sharply defined plaques or marked multiple polyp formation.


NE: There is necrosis of the underlying PIA lesion resulting in yellow/grey cheesy masses that adhere tightly to the wall.


RI: The lower intestine becomes thickened and ridged. Often referred to as hosepipe gut. Ulceration can be often be seen in the mucosa.


PHE: The small and large intestines are dilated and filled with a blood clot. The colon contains black tarry faeces. The intestinal contents are rarely liquid. The intestines bulge out of the abdomen once opened.The aetiological agent is Lawsonia intracellularis, a Gram-negative, obligate intracellular bacterium and member of the Desufovibrionaceae family. The incubation period after infection is around two to three weeks. The organism lives inside the epithelial cells lining the intestine (enterocytes), which leads to active cell proliferation and a thickening of the gut wall. This reduces the absorptive efficiency of the gut leading to depression of growth and feed efficiency by about 10 to 20 per cent.

Lawsonia intracellularis is transmitted from pig to pig by an oral–faecal route. Nursing piglets may be first exposed to the disease via the sow’s faecal material. After weaning, the disease may be spread from older, infected pigs to young, susceptible pigs. Once infected by the organism, clinical signs may appear within 10 to 14 days and the organism is shed in the faeces for weeks. The presence of carrier animals in populations of pigs has been suspected to be a source of infection, but this has not been substantiated or characterised. Birds, rodents and contaminated equipment can also spread the disease.

Disease Forms
Chronic form (weaners, growers)
Pigs usually appear clinically normal, and still eat well during the initial stages. There is chronic watery diarrhoea, followed by gradual wasting and loss of body condition

 
In some cases, there may be a pot-bellied, bloated appearance. Pigs with the chronic form of ileitis may sometimes recover over a period of four to six weeks, however, there can be considerable losses in feed efficiency and daily gain of up to 0.3 and 80g per day respectively. As a consequence, there can be marked variations in sizes of pigs and poor uniformity in the herd. NI or RI may follow from it with similar signs, with necrosis in the distal portion of the small intestines and proliferation of the small intestinal cells, which die and are sloughed off with a gross thickening of the small intestine or ‘hosepipe gut.’ In the chronic form of the disease, the symptoms may be masked by other conditions, such as respiratory problems.

Acute haemorrhagic form (fattening pigs; sows, gilts in breeding stock)
This form usually affects pigs between the ages of four to 12 months. It normally affects gilts, especially those that are newly bought, seven to 10 days after being transferred to a commercial farm, during the stress period. Gilts in both commercial and genetic farms are affected, and many die from the disease.

In the case of fattening pigs, ileitis can affect growers as well as finishers right up to seven to 10 days before slaughter. Many of the affected pigs die from haemorrhagic ileitis. This is because very little attention is usually given to these fatteners, as most focus on the sows on heat, gestating sows and lactating sows. Because the disease is acute, in no time, the pig farmers start to realise that they are losing their pigs to ileitis, and by then, it is usually too late.

 
Usually the finishers that are affected are those of top quality and the heaviest of the herd. Death is sudden, with blood from the anus, similar to that of swine dysentery but without the mucous and there is usually mucosal and cutaneous pallor.




Treatment and Control
In clinical and laboratory testing, a series of antibiotics such as tylosin, tiamulin, valnemulin, lincomycin and other tetracyclines are potentially effective. However, disease eradication seems impossible commercially, as reports have indicated disease recurrence upon cessation of the antibiotic treatment period, or at least Lawsonia shedding some weeks post-treatment.

Another problem faced with the medications used to treat ileitis is that there is always a withdrawal period, so pig farmers would have to keep their animals for a longer period of time before they can be sold and this usually disrupts their schedule or turnover cycle. In-feed antibiotics such as tiamulin and tylosin have been shown to be not very effective and treatment response to these drugs has been poor of the late, probably due to resistance.

Even if injectables are used, 20 per cent of the best pigs of those affected will still die from ileitis, and only 50 to 60 per cent will survive. These injectables have to be given two or three times, 12 hours apart. In the process of separating and injecting the animals, stress will usually kill some of the affected pigs. The cost and extent of labour is also extensive in injecting affected pigs. Thus it is a well-known fact that ileitis causes significant economic losses to the pig producer.

Orego-Stim and Pig Ileitis
Orego-Stim is very effective for the treatment and control of ileitis. In many herds with ileitis history, its application as a growth enhancer contributed significantly to reduce or even eliminate subclinical and chronic forms of the disease, without need for treatment. The absence of Lawsonia infection and intestinal lesions has been demonstrated using PCR and histopathology.

For effective ileitis prevention, Orego-Stim Powder is typically included at 1kg per tonne for the first two weeks postweaning or up to 15kg bodyweight, followed by 500g per tonne up to the start of the growing period or 25kg bodyweight, and finally 250g per tonne throughout the grower-finisher period up to slaughter. In cases of severe acute haemorrhagic ileitis, it is recommended to include Orego-Stim Liquid at 500ml per 1000 litres of drinking water during the first two days of treatment, followed by Orego-Stim Powder at 500g per tonne for the next five days, and finally Orego-Stim Powder at 250g per tonne for another week. Results are usually seen within 12 to 18 hours, where affected animals regain their appetite and start eating again. Producers affected by the haemorrhagic form are encouraged to conduct trials using the above recommendations in comparison to their current ileitis treatment regime, as soon as ileitis is suspected in a herd. The farmer should be able to note a reduction in death losses.

For chronic ileitis, treatment should be started one month before the usual onset of clinical signs. To prevent ileitis from spreading to a healthy group, start treatment before the observation of first clinical signs of ileitis in the diseased group. For both the diseased group and preventive group, double inclusion rate of Orego-Stim during the first week of treatment. For short-term treatment, Orego-Stim Liquid may be used, at half the inclusion rate of Orego-Stim Powder.

[rialex]

nice info, thanks dito sir. ang laking tulong 

[jenny_pretty18]

Good day po..
Is Porcine Intestinal Adenomatosus the same with rectal prolapse (parang almoranas)?
We have a piglet (2 mos.) with a rectal prolapse..
A technician who visited our farm told us to to give a cold compress like ice to the prolapse rectum..
Is it okay? Is there anyway we can do to the prolapse rectum? We're afraid that if the prolapsed rectum turns black, we needed to dispose the piglet already?
Please do help us with the necessary solution..

Thanks and God bless..

[rye0528]

Miss Jenny,

Re sa rectal prolapse, sometimes bumabalik po ito ng kusa as long na naaaddress ang nagccause nito. Sa akin po eh pinapractice kong ibalik ang prolapsed rectum. Cold compress is good pero ako i use luke warm water with sugar para madaling umimpis ang pamamaga. Then try to give parenteral antiobiotics.

Ryan

[rye0528]

Good day po..
Is Porcine Intestinal Adenomatosus the same with rectal prolapse (parang almoranas)?
We have a piglet (2 mos.) with a rectal prolapse..
A technician who visited our farm told us to to give a cold compress like ice to the prolapse rectum..
Is it okay? Is there anyway we can do to the prolapse rectum? We're afraid that if the prolapsed rectum turns black, we needed to dispose the piglet already?
Please do help us with the necessary solution..

Thanks and God bless..
 

PIA is different from Rectal prolapse. PIA is a intestinal disease cause by bacteria (par. Lawsonia spp.) while rectal prolapse is the protrusion of part the large intestine due to intestinal parasite or other factor na nagdudulot ng pressure sa abdomen ng hayop.

[sanico]

Sir Ryan, When you say Parenteral Antibiotics, can you please name that particular antibiotics
which are available in the market ? Thanks

Miss Jenny,

Re sa rectal prolapse, sometimes bumabalik po ito ng kusa as long na naaaddress ang nagccause nito. Sa akin po eh pinapractice kong ibalik ang prolapsed rectum. Cold compress is good pero ako i use luke warm water with sugar para madaling umimpis ang pamamaga. Then try to give parenteral antiobiotics.

Ryan

[rye0528]

Almost all of the antibiotic in the market are given parenterally. Common antibiotics are oxytetracycline, amoxiillin, penicillin, enrofloxacin, florfenicol at madami pa pong iba.

[jenny_pretty18]

Miss Jenny,

Re sa rectal prolapse, sometimes bumabalik po ito ng kusa as long na naaaddress ang nagccause nito. Sa akin po eh pinapractice kong ibalik ang prolapsed rectum. Cold compress is good pero ako i use luke warm water with sugar para madaling umimpis ang pamamaga. Then try to give parenteral antiobiotics.

Ryan

Thanks po sa advice.. 
Yun po bang lukewarm water with sugar ang ipanghuhugas namin sa prolapsed rectum?
Intayin po ba namin na umimpis muna before ibalik yung prolapsed rectum?

Thanks again and God bless po..

[sanico]

Sir Ryan,
Which one do you recommend for rectum prolapse ?

Almost all of the antibiotic in the market are given parenterally. Common antibiotics are oxytetracycline, amoxiillin, penicillin, enrofloxacin, florfenicol at madami pa pong iba.

[rye0528]

Miss Jenny,

Hindi po. You can use the lukewarm water to wash the prolapsed rectum then try to push it back inside. it woul be a lot easier.

Ryan

Mr. Sanico,

Lahat po ng nabanggit ko eh broad spectrum antibiotics, long acting antibiotics is recommended like OTC.

Ryan

[jenny_pretty18]

Maraming Salamat po Sir Ryan..

We'll try it later..

May tendency po kayang magprolapsed ulit ito kahit naibalik na?

Thanks again and God bless po..

[rye0528]

MIss Jenny,

Meron po tendency na bumalik if ung nagcacause ng prolapse eh bumalik ulit. Pag nagprolapse po ulit better na ibalik or treat nyo then sell it na lang.

Ryan

[jenny_pretty18]

Good day po Sir Ryan..

D na po namin natry na ibalik yung prolapsed rectum kasi po namamaga po and 2-3 inches na po yung nakalabas..
Nakakatakot na po ibalik..
Binenta na lang po namin siya..
Thanks po sa mga advice..
God bless po..

[sanico]

Sir Ryan,
We have one sow, everytime after 3-5 days of farrowing ay lumalabas ang rectum ( prolapsed rectum )
at we push it back. Then after weaning nawawala man lang until na mabuntis ulit and give birth.
Ano kaya ang mabuting gamot dito to cure the prolapsed rectum during lactation period ?
Is it hereditary to its piglets ?
Thanks.

Miss Jenny,

Hindi po. You can use the lukewarm water to wash the prolapsed rectum then try to push it back inside. it woul be a lot easier.

Ryan

Mr. Sanico,

Lahat po ng nabanggit ko eh broad spectrum antibiotics, long acting antibiotics is recommended like OTC.

Ryan